Chronic Constipation Caused by Neurofibromatous Proliferation in A Case of Von Recklinghausen´s Disease – A Case Report
Published: September 1, 2013 | DOI: https://doi.org/10.7860/JCDR/2013/.3384
Honnappa Sridha, Rau R Aarathi, Mysorekar Vijaya, Jalihal Umesh
1. Assistant Professor, Department of Pathology, M.S. Ramaiah Medical College, Bangalore, Karnataka, India.
2. Professor, Department of Pathology, M.S. Ramaiah Medical College, Bangalore, Karnataka, India.
3. Professor, Department of Pathology, M.S. Ramaiah Medical College, Bangalore, Karnataka, India.
4. Professor, Department of Gastroenterology, M.S. Ramaiah Medical College, Bangalore, Karnataka, India.
Correspondence
Dr. Honnappa Sridhar,
Assistant Professor, Department of Pathology, M.S. Ramaiah Medical College.
Phone Number: 080-23605190, Fax: 080-23606213,
Mobile: 09742341871, E-mail: drsridhar24@rediffmail.com
Neurofibromatosis (NF) is an autosomal dominant genetic disorder with a myriad of clinical manifestations . A gastrointestinal involvement which is present in 10 -25% of patients, is usually a systemic manifestation of generalised NF. We are describing a case of NF 1 with chronic constipation, in whom colonoscopy revealed a thickening of the colon wall with narrowing. A mucosal biopsy showed neural hyperplasia .This case emphasizes the value of minimally invasive endoscopic biopsies of GI lesions in NF1, where despite a limited sampling, correlation with clinical and endoscopic features may help in reaching a diagnosis of a neurofibromatous proliferation. We have also discussed the differential diagnosis of gastrointestinal lesions in NF with neural hyperplasia.
[
FULL TEXT ] | [ PDF]